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Cell-surface proteoglycans as molecular portals for cationic peptide and polymer entry into cells

Thus, substitution of (replacing rather than adding) an agent with cardiorenal benefit might be appropriate if people are at or near A1c target

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Preclinical studies have shown that TUDCA helps prevent neurodegeneration and reduces insulin sensitivity from chronic toxin exposure or metabolic stressxvi

It stimulates nerve branching (neurite outgrowth), allowing neurons to wire together

Overproduction of GRX1 in INS-1 832/13 cells and isolated rat islets also stimulates insulin exocytosis [90]