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It is important for patients to report any unusual or concerning symptoms to their healthcare provider, as individual responses to medication can vary significantly

Many patients beginning treatment notice changes in their lipid panel within weeks to months

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However, clinical trial results have been mixed

17(12):e1003228 Doumouras AG, Hong D, Lee Y, Tarride JE, Paterson JM, Anvari M (2020) Association between bariatric surgery and all-cause mortality: a population-based matched cohort study in a universal health care system

The SELECT trial (N=17,604), published in the New England Journal of Medicine in 2023, showed that semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% in overweight or obese adults without diabetes over a median follow-up of 34.2 months