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PS exposure by infected cells has been linked with an increase in their cytoadhesion and sequestration, both in P

People undergoing chemotherapy or radiation therapy : These treatments can cause oxidative damage and deplete glutathione levels, making it harder for the body to recover

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This localized buildup of toxic byproducts further degrades the endothelial lining, worsening the circulation issues

This multifaceted process is best understood not as a linear sequence of events but as a self-perpetuating immunopathological circuit, where feedback between the immune system and epidermal cells amplifies the inflammatory response (Baliwag et al