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Studies have indicated that uric acid crystals can engage with Toll-like receptors (TLRs), which are membrane-bound receptors integral to innate immunity, thereby inducing inflammation

1995 Feb;42(2):191-4

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You can change your mind at any time and increase your dose with your doctors approval, as long as its been at least 4 weeks on your current dose but you cannot take more than 2.4mg a week

In more serious cases, it can affect the heart muscle or liver

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