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An intravenous infusion of GLP-1 is capable to completely normalized blood glucose levels in patients with long-standing type 2 diabetes that cannot be controlled with sulphonylurea therapy.33 As well as OXM, GLP-1 is released rapidly into the circulation after oral nutrient ingestion (from 5 to 30min) and in proportion to meal calorie intake, inhibiting both gastric acid secretion and motility