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BMS536924, a dual inhibitor of insulin-like growth factor (IGF) and insulin receptors, has been found to exert iron-chelating and ferroptosis-inhibitory effects [42]

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Second, crossing Jnk1 LoxP/LoxP / Jnk2 -/- mice with Alb-Cre mice deletes Jnk1 in hepatocytes during embryogenesis, raising the possibility of compensatory gene induction that could interfere with the final outcome