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DNA demethylating drugs are thought to de-repress epigenetically silenced tumour suppressor genes as well as demethylate endogenous retroviruses (ERVs), triggering an antiviral immune response and cancer cell death (Chiappinelli et al , 2015

It is remarkable that Vssc mutations have expanded greatly over the last three decades (Table 1) but that the specific mutations that confer the resistance have yet to be identified

The impact on periods therefore varies considerably depending on individual circumstances and underlying reproductive health

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