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Avoid high-fat meals near dosing for best absorption

GLP-1 carries most of the appetite effect, glucagon drives much of the liver- and visceral-fat loss, and GIP improves insulin handling while buffering some GLP-1-related nausea

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Clinical guidelines, as the post describes them, favor risk stratification with close monitoring over automatic exclusion

The landmark 2017 Cell study (Baar MP et al., PMID: 28340339) demonstrated that: (1) FOXO4 protein specifically accumulates in senescent cells where it binds to p53 and prevents p53 from triggering apoptosis (this is the specific mechanism being targeted)

Manganese also supports the formation of collagen, which is required for optimal cartilage structure and integrity