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Oliveira SR, de Arruda JAA, Corra JD, Carvalho VF, Medeiros JD, Schneider AH, et al

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On the right, the selenium-dependent glutathione peroxidase oxidizes two molecules of GSH back to GSSG in a reaction that converts one molecule of hydrogen peroxide (H 2 O 2 ) into two molecules of water (H 2 O)

This is accompanied by mitochondrial dysfunction, oxidative stress, and neuroinflammation, ultimately triggering neuronal decline (Sturm et al., 2014)

35 Cerebral edema and intracranial hypertension Cerebral edema is the leading cause of death in patients with acute liver failure, and it develops in nearly 40% of patients