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41589_2021_915_MOESM14_ESM.mpeg Supplementary Video 12 Representative movie for 100 ns MD simulation of GPX4 K48L with the camera zoomed in for a close-up of the active site

Engineered for metabolic research protocols requiring sustained activity profiles

The practical result is that IGF-1 LR3 requires once-daily dosing and circulates freely in plasma longer, producing sustained receptor activation whereas native IGF-1 would require continuous infusion to maintain therapeutic levels

In this article we have highlighted many different astrocyte-associated molecules that are emerging as potential therapeutic targets in different disorder contexts

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