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As a physician, I often prescribe GLP-1 agonists to help manage weight and blood sugar levels in patients with obesity and diabetes

doi: 10.1016/j.npep.2018.07.003

Starting at higher doses or jumping dose strengths increases your risk for more severe side effects

GI side effects common during titration

A 2025 systematic review and meta-analysis of tirzepatide (Masson and colleagues, Reviews in Endocrine and Metabolic Disorders ) found that across seven randomized trials, tirzepatide reduced hsCRP by about 33% and IL-6 by about 18% compared to placebo and the effect held even at the lowest 5 mg dose

Effects of bitter substances on GI function, energy intake and glycaemia-do preclinical findings translate to outcomes in humans