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For sustained elevation, regular moderate-to-vigorous cardio lasting 30 to 40 minutes, performed four to five times weekly, maintains elevated BDNF for up to 24 hours after each session

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For example, a randomized controlled trial in 2014 involving about 370 patients with osteoarthritis in the knee found that curcumin was just as effective as ibuprofen for reducing inflammation, swelling, and pain but with far fewer gastrointestinal side effects

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Often reversible if treated promptly