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doi: 10.3389/fmolb.2026.1791536 Received 19 January 2026 Revised 22 March 2026 Accepted 27 March 2026 Published 23 April 2026 Volume 13 - 2026 Edited by Javeed Ahmad Bhat, University of Rochester, United States Reviewed by Ilyas Beg, National Institutes of Health (NIH), United States Vahid Saqagandomabadi, University of Palermo, Italy Updates Copyright 2026 Pustovaya, Venediktov, Soldatov, Kuzmin, Pokidova, Gartzeva, Payushina, Tsytsarev, Meglinski and Piavchenko

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1 These mechanisms often overlap, which is why a single lip can present darkening from multiple sources at once

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In WT C57BL/6 male mice, systemic inhibition of DPP-4 activity with sitagliptin reduced TG excursion following oral olive oil gavage during a lipid tolerance test (LTT) (Figure 1C)

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Navigating the complexities of GLP-1 therapy can often be daunting

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BBB Permeation Rate The BBB permeation rate provides an estimate of the unidirectional transport of a drug across the BBB, which is different from the extent of equilibrated drug transport across the BBB at steady state

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