Researchers became interested in this combination because early studies suggested that adding amylin pathway modulation to triple incretin agonism could produce synergistic effects beyond either component alone similar to how the CagriSema (cagrilintide + GLP1) combination outperformed individual components in clinical trials
Helps reduce fasting blood sugar levels
This is particularly important when one of the components has a narrow therapeutic window
Kreider RB, Kalman DS, Antonio J, et al
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But, except in the case of medical treatment for kidney failure and other conditions, taking by mouth is effective and simpler