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Distal cholangiocarcinoma is a rare and aggressive form of bile duct cancer with limited treatment options, highlighting the significant unmet need that the OncoSil device aims to address

A phase III clinical trial examining lapatinib, a dual EGFR/HER-2 tyrosine kinase inhibitor that inhibits the EGFR/HER-2 signaling pathway, has shown that lapatinib reverses resistance to trastuzumab in patients with breast cancer with trastuzumab resistance 86 ( Table 1 )

Other nanoparticle approaches are earlier in development [96]

Injection technique optimization includes: Site rotation systematically alternating injection locations to prevent tissue trauma and lipohypertrophy Proper administration following the manufacturer's Instructions for Use for Mounjaro or Zepbound pens regarding proper technique Room temperature medication allowing the pen to reach room temperature before injection reduces discomfort Skin preparation cleaning the injection site with alcohol and allowing it to dry completely Avoiding scarred or damaged skin selecting healthy tissue free from previous reactions, bruising, or inflammation For mild injection site reactions, conservative management is typically sufficient

Stay minimum 4 weeks per dose level before increasing

Ezra Aksoy, Queen Mary University of London, UK Updates Copyright 2016 Zietek and Rath