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Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

This is mechanistically different from GLP-1 receptor agonists like semaglutide or tirzepatide, which are large peptide chains stabilised by complex tertiary structures that degrade slowly even at suboptimal temperatures

Vitamin B12 is generally considered safe and non-toxic, even at high doses, because it is water-soluble

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PubMed Hartman, M.L., Sanyal, A.J., Loomba, R., Wilson, J.M., Nikooienejad, A., Bray, R., et al