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Complementary and alternative medicine use in a large pediatric autism sample

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Conditions for which this effect has been demonstrated are: glutaric aciduria II, methyl malonic aciduria, propionic acidemia, and medium chain fatty acylCoA dehydrogenase deficiency.7,8 Autointoxication occurs in these patients due to the accumulation of acylCoA compounds that disrupt intermediary metabolism

The concern is not theoretical: excess GH from any cause, including GH-secreting adenomas in adolescence, is associated with accelerated bone age and, paradoxically, shorter final stature if epiphyses close early [10]

In the connection between mitochondrial metabolism and aging, prior work reported decreased levels of LAC in subjects with Alzheimers disease (AD) as compared to cognitively healthy controls, with intermediate levels in subjects with subjective memory complaint or mild cognitive impairment [64]