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This mechanism, whilst protective from an evolutionary standpoint, can manifest as persistent feelings of coldness, particularly in the extremities

As part of the PIONEER REAL study programme, it shares a similar study design, study procedure and study endpoints with the published PIONEER REAL Switzerland study [26]

In June 2023, Lilly reported that Orforglipron led to an average weight loss of up to 14.7% over 36 weeks in adults with obesity or overweight based on Phase II trial results