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According to Pisoschi et al

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doi: 10.1080/07315724.2019.1685332

Pillai et al., 2023)

SubQ injections create a sustained-release depot in adipose tissue with absorption spanning 46 hours, while IM bypasses adipose entirely and dumps peptides directly into vascular muscle tissue for peak plasma levels within 6090 minutes

Ipamorelin may be considered by providers exploring metabolic optimization or lean muscle support, but patient selection should include baseline metabolic screening, glucose monitoring, and realistic expectations about evidence limitations