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What the evidence says about bakuchiol and retinol The most relevant direct comparison is a 12-week randomized, double-blind trial using 0.5% bakuchiol cream twice daily versus 0.5% retinol cream twice daily

Nelson M, Balasundaram G, Webster TJ

& Wu, Z.-Y

Biomarkers So far, many biomarkers have been reported to indicate BBB damage, but none of them meets all the characteristics for an ideal biomarker (high specificity, sensitivity, and reliability, easy and fast assessment, and minimal invasiveness) (161)

So far, there are very few risk signals from the academic papers, very few risk signals from the patient and doctor experience, and then very strong efficacy signals, says Marchione, who is not medically trained

The concentration of BPC-157 research within a single laboratory group is a notable limitation