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The third term is the loss of cysteine in the reaction catalyzed by GCS that makes glutamyl-cysteine and the fourth term represents the loss of cysteine to other pathways (for example to sulfate and taurine)

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After years of frequent contraction, those wrinkles can linger even after the muscles are at rest

This shift indicates a movement of the excitation-inhibition balance towards excitation, promoting faster motor information processing (Thacker et al., 2019)