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The contribution of fatty acid metabolism is another challenge, especially for the better reproduction of energy metabolism in obese patients ( in vivo and in vitro experiments, contributing to a better understanding and prediction of complex biological systems ( To conclude, we integrated multiple metabolic zonation models into a single numerical human liver model and validated it with the results and observations of previous reports in a semi-quantitative manner

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5.1.1.2 Oxidative stress markers In migraine patients, levels of malondialdehyde (MDA) are significantly elevated, especially in cases of migraine with aura, reflecting increased lipid peroxidation and oxidative stress damage (Tuncel et al., 2008)