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However, a 2015 review article suggests that increased IP may contribute to the development of inflammatory bowel disease (IBD)

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More significant changes in thickness and density are typically seen after 36 months of consistent use

10.1038/s41419-024-07244-x 151 ZhongG.WangX.LiJ.XieZ.WuQ.ChenJ.et al (2024)

Trends Endocrinol Metab 21(2):5967