The clinical caution: rapid weight loss (more than 2 pounds per week sustained) increases the risk of gallstones, lean mass loss, and rebound hunger when one medication is later stopped or reduced
doi: Dou Y, Lee A, Zhu L, Morton J, Ladiges W
Semaglutide does not directly suppress cortisol production, but it may indirectly support healthier cortisol patterns by reducing metabolic stress, stabilizing blood sugar, and lowering systemic inflammation
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According to NICE Guidelines, GLP-1 medications such as semaglutide can be prescribed for weight management in certain patients when lifestyle changes alone have not been effective