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It has also been shown that enzyme induction of phase II enzymes can lead to hepatomegaly without hepatocellular hypertrophy (Makino et al

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Kodali et al., 2018

After anesthesia, the experimental animals were placed in a ventral position and maintained at a core temperature of approximately 37.0 C using a heating pad

Patients should be especially diligent about moisturizing daily while taking Accutane in the winter, as low humidity and cold temperatures can worsen dryness