The mechanisms of neuronal plasticity include the regulation of synaptic strength (i.e., synaptic plasticity), structural remodeling, as well as the regulation of intrinsic characteristics of neurons, like excitability or firing rate ( The changes in neurotrophic factors lay the basis for impaired neural plasticity, which is directly linked to the onset and progression of depression
In a study by Jalota Badhawar et al., a TAT-SMAR1-derived chimeric peptide (p44) considerably activated p53 by phosphorylating serine 15, via activating p21 protein and inhibiting cell cycle progression [56]
As a GLP-1 receptor agonist, it regulates appetite and improves blood sugar control, making it suitable for those with obesity or related health issues
1 Introduction Garlic ( Allium sativum L.) is a member of the Liliaceae family ( Allium contain hundreds of species, including garlic, onion, shallot, leek and chive, that are known for their physiologically active secondary metabolites ( The raw garlic-derived compounds contain organosulfur components susceptible to oxidation, volatilization, and deterioration when exposed to unfavorable conditions such as light, oxygen, and high temperatures ( This comprehensive review provides recent experimental and clinical reports
However, suppression of IRP1 by alpha-enolase (ENO1) protects hepatocellular carcinoma cells from ferroptotic cell death [25]
However, the low carnitine levels were not associated with increased depression and fatigue and taking l-carnitine for a month did not improve depression or fatigue in these 11 individuals
