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Pharmacological activation of amp-activated protein kinase ameliorates liver fibrosis in a metabolic dysfunction-associated steatohepatitis mouse model

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A 6-week phase 1 SAD study in lean and overweight participants shows a mean weight loss ranging 1.8% to 3.3% in the higher dose groups (3.5-6.0 mg), compared to weight gain of 1% for the placebo groups ( 3.5 GLP-1/glucagon receptor agonists (oxyntomodulin analogues) 3.5.1 Mazdutide Oxyntomodulin is a proglucagon fragment that activates both GLP-1 and glucagon receptors