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doi: 10.1016/j.biomaterials.2012.09.051

Splitting a bulk order into smaller vials and reconstituting one at a time extends usable product life significantly compared to reconstituting the entire supply upfront

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A 2026 review in the New England Journal of Medicine noted that questions about long-term dosing and durability of results remain open areas of research, not settled strategy

Do not expose to heat, light or humidity

Some dont feel any effect, whereas others get headaches