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Cognitive impairment, defined as an intermediate stage between the normal aging process and the onset of dementia, has a multifaceted etiology but specifically in the setting of metabolic disorders is sustained by a spectrum of factors, prominently featuring IR, lipotoxicity, and vascular-systemic inflammation, which are also shared with MASLD

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Figure 5 This chapter investigates the mechanisms underlying BA metabolic dysregulation in gout

Second, references from the retrieved systematic reviews were screened to ensure that all relevant primary studies were included in this scoping review

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