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In 2021, the Amgen team published the preclinical research progress of their dual-function molecule project AMG 133, which involves GIPR antibodies and GLP-1R, for the first time in "Cell Reports Medicine"

Furthermore, one study has shown that the cyclic peptide DC646 binds to K303 in the ligand-binding domain (LBD) of FXR, triggering conformational changes in the LBD and inhibiting recruitment of the coactivator SRC2 [58]

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A larger follow-up RCT (n=72 older adults) confirmed these findings, additionally demonstrating improvements in gait speed (+0.14 m/s), grip strength, 6-minute walk distance, waist circumference reduction, and systolic blood pressure reduction (Kumar et al., J Gerontol A Biol Sci Med Sci, 2023) [21]

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