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54, 55, 56 Interestingly, one of the claudin family proteins, claudin-7, when expressed in intestinal epithelium demonstrates a prominent basolateral membrane distribution compared with other claudins that localize primarily to the apical TJs in the intestinal epithelium

A 4-week on period provides a significant therapeutic stimulus without the high risk of diminished returns often seen in longer, multi-month cycles [4, 5]

References 1

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Treatment with picomolar to nanomolar concentrations of Dihexa produces dose-dependent increases in spine density, with maximal effects observed at 10-12 M concentrations