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As long as alcohol consumption continues, it is difficult to know how much thiamine to give to correct the deficiency because the alcohol will continue to interfere with thiamine being properly absorbed and converted to its active form

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For a long time, OMM was considered an innocuous lesion without a potential of malignant changes until a few cases of transformation into the primary oral melanoma were described by Taylor and Lewis in 1990 (17), Kahn et al

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