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Recent data have indicated that such an effect may depend on the influence on metabolic processes because in chronic unpredictable mild stress (CUMS) in mice, the decreased GLP-1 level in the hippocampus was increased with metformin treatment [46]

GLP-1 RAs are acknowledged for their role in maintaining glucose homeostasis and exerting a range of broader biological effects, including cardioprotective properties

I mean the mitochondria is complex

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When metabolic signals become dysregulated, traditional approaches can feel ineffective