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ASC/overlap can be differentiated from typical AIH by a lesser female predisposition, high serum alkaline phosphatase to aspartate aminotransferase (AST) ratio, presence of peri-nuclear anti-neutrophil cytoplasmic antibodies (p-ANCA), stronger association with inflammatory bowel disease (IBD), and a worse prognosis than typical AIH

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Mycotoxin exposure can come from both dietary and environmental sources

The utilization of N-acetyl cysteine (NAC) and the PI3K inhibitor (Ly294002) successfully inhibits the upregulation of AKR1C3 protein induced by cadmium