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It is noteworthy that these anti-inflammatory effects exerted by dopaminergic signaling in astrocytes are mediated by D1R and D2R, while D3R mediates the pro-inflammatory effects ( D1R D1R signaling participates in the negative regulation of the activation of NLRP3 inflammasome, which can be assembled upon stimulation with accumulated endogenous metabolites such as fibrillar amyloid and 25-hydroxycholesterol (113), the subsequent secretion of caspase-1 and IL-1 contributes to the destruction of dopaminergic neurons (114)

Vitamin C neutralizes daily aggressors while boosting Glutathiones effect

Assuming that allulose is supplemented in similar products as those found in the USA or Japan and by taking food consumption levels relevant for Europe into account (e.g

doi:10.1016/j.ejphar.2004.03.027 85

doi: 10.1016/j.colsurfa.2020.125235 77 GirardonMParantSMonariADehezFChipotCRogalskaEet al

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