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Rapid correction of glycaemia with resultant optic nerve swelling has been hypothesised as a factor

This risk may be higher: During the first few months of treatment After a dose increase or decrease When starting or stopping the medication Its important to watch for sudden or unusual changes, such as: New or worsening depression Thoughts about self-harm or suicide Increased anxiety, agitation, or restlessness Panic attacks or irritability Trouble sleeping Acting impulsively or out of character Caregivers and patients should monitor for these changes closely and contact a health care provider right away if concerning symptoms appear

Pajares M, Rojo AI, Manda G, Bosca L, Cuadrado A

A., Strauss, E., Guo, W., Noszl, B

Some are available as nasal sprays, capsules, or creams