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Tirzepatide: The New Contender Tirzepatide is a newer medication that acts on both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, making it a dual agonist

"Our nomination provides numerous examples of these risks, including unknown impurities, peptide-related impurities, incorrect strengths, and even instances where no semaglutide was present in the product at all," Novo Nordisk spokesperson Jamie Bennet wrote in an email to NPR

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[1] [2] As a peptide medication, semaglutide requires specific storage conditions to maintain its stability, potency, and safety throughout its shelf life

Constipation is the most persistent issue, affecting 15 to 20 percent of long-term users