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Adequate hydration preserves GLP-1's kidney-protective benefits while avoiding the dehydration-related stress that could temporarily elevate kidney markers

10.1016/j.pcad.2018.02.001 70 OnoderaY.TeramuraT.TakeharaT.ShigiK.FukudaK

The nucleus contains finely dispersed chromatin that is similar to that of neuroendocrine cells and occasionally a single, inconspicuous nucleolus

This phenomenon occurs because tolerance to these effects can diminish during treatment gaps

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Moreover, it is worth to underline the need of exploring the role of iron-mediated oxidative damage through Fenton reaction to further ascertain the contribution of mitochondrial dysfunction and iron accumulation to the progression and pathologic development of age-related diseases