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References Mechanism of Action 1-4 Tirzepatide exerts its effects through dual incretin receptor agonism, targeting both: Niacinamide 5-7 Niacinamide contributes to supporting mitochondrial function and metabolic pathways through its conversion to NAD/NADP.It is a vital component in the oxidized state of nicotinamide adenine dinucleotide (NAD, or coenzyme 1) and the reduced form of nicotinamide adenine dinucleotide phosphate (NADP, or coenzyme 2)

Nrf2 itself is regulated by the Keap1 protein, which sequesters Nrf2 in the cytoplasm under normal conditions

Novo named the higher-dose version Wegovy

doi:10.1126/scitranslmed.aay8071 37