Polymeric nanoparticles (e.g., PLGA) can improve solubility and exposure with strong regulatory precedent, but degradation-driven release may be less programmable for multi-trigger redox logic ( A pragmatic decision rule is as follows: choose MSNs when the primary requirement is architectural control over interfacial redox kinetics (stability + conditional release) and when a safety/reproducibility package can be credibly assembled
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Ferrous iron drives ferroptosis, a regulated cell death program genetically and biochemically distinct from apoptosis, necrosis and autophagic cell death (Dixon et al., 2012)
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5, 7.5, and 10 M PR619 for 24 h were used to assess the impact of DUB inhibition on the proteasome