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Similar content being viewed by others Facts Melatonin is a ubiquitous molecule with natural and powerful antioxidant proprieties and administration of exogenous melatonin is safe Melatonin exerts anti-inflammatory effects mainly by inhibiting inflammasome activation Melatonin exerts its antiapoptotic activities mainly by blocking caspase 3 cleavage and mPTP opening Oxygen radical diseases of neonatology refers to the oxidative stress that has a leading role in the pathogenesis of neonatal morbidities and pathologic conditions Open questions How endogenous melatonin contrast the oxidative stress that has a leading role in the pathogenesis of neonatal morbidities and pathologic conditions