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In a study conducted on rats with ASD, it was observed that the NAA/total creatine (tCr) ratio, glutamate/GABA ratio and tCr level in the prefrontal cortex were substantially associated with the lack of social behavior in rats [60]

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The initial step of the synthesis involves the conversion of cholesterol to pregnenolone by cytochrome P450 side-chain cleavage enzyme 11A1 on mitochondrial membrane