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The McCoy 2013 paper extended this work by introducing N- and C-terminal modifications designed to enhance metabolic stability and hydrophobicity, ultimately producing Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) as an orally active, BBB-permeable analog [2]

Some studies show a small increase in resting metabolic rate, possibly mediated by improved insulin sensitivity and reduced lipotoxicity in tissues

The location of the target dictates the general area for application

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IGF-1 LR3 1mg IGF-1 LR3 (Long Arg3) is an 83 amino acid analogue of recombinant human insulin-like growth factor 1, modified with an N-terminal extension and an arginine-for-glutamic-acid substitution at position 3

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