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We propose that curcumin exerts its broad therapeutic effects via a unified inflammationoxidative stress axis, primarily by inhibiting NF-B and NLRP3 activation, reducing ROS and pro-inflammatory cytokines (TNF-, IL-1/18), as seen across models of depression, metabolic disorders, and neurodegeneration

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Firstly, the modified bacteria have the inherent ability to target hypoxic areas of tumors and can achieve high-density colonization within the tumors

Thymulin also prevented LPS-induced up-regulation of production of several cytokines by spleen lymphocytes and peritoneal macrophages