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This phenomenon, sometimes referred to as early worsening of diabetic retinopathy, appears to be related to the magnitude and speed of glucose lowering rather than a direct effect of the medication

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Sorensen and colleagues (31) set out to examine if altered levels of synaptic vesicle zinc during the course of focal ischemia could be detected histochemically (32)

Notably, participants in the 12mg group had not reached a weight loss plateau at 48 weeks, suggesting that longer treatment durations could yield even greater reductions

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