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To improve the selectivity, in this work, we design and synthesize a malononitrile-functionalized TPE derivative, TPE-DCV, which can undergo addition reaction with thiol group to the alkene bond, leading to the change in its fluorescence in the system (Figure 1)

These distinct sequence features may provide the basis for the different structural modules of GLP-1R and GCGR, as well as diverse pathways for conformational change during peptide binding and activation

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This combination of sterile water and benzyl alcohol allows multiple withdrawals to be made from a single 30ML amber glass vial

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Beyond improving health, these medications enhance quality of life and lower the risk of life-threatening events, including strokes, heart failure, and all-cause mortality