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In this study, we show that semaglutide was associated with a significant 20%-46% reduction in overall ADRD incidence

"We speculate that semaglutide shows an anti-inflammatory effect by promoting the transformation of microglia from M1 to M2 type in the brain of 3xTg mice, and thus exerts a neuroprotective effect," write the researchers

The numbers are not small

First dose timing: The timing of your first oral GLP-1 dose can also depend on how long your previous injection stays active in your body

Tirzepatide binds the GLP-1 receptor with lower affinity than semaglutide and exhibits distinct signaling bias, which may result in comparatively different downstream GLP-1 receptor signaling dynamics 23

Nesheiwat stressed