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Kidneys cannot clear extra fluid, vitamins, and minerals, so IV drips can cause fluid overload and dangerous electrolyte buildup (especially potassium and magnesium)

Another potent oral PARP1/2 inhibitor, niraparib (MK4827) binds to the active site of PARP enzymes, and studies indicate that Niraparib can restore NAD + levels and improve mitochondrial function 165,166