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Months 1 to 3: the neurochemical phase As semaglutide reaches therapeutic levels and the brain adapts to altered GLP-1 signaling, changes in reward processing become more apparent

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Whereas the nonopioid patient group showed a deactivation in this region

Furthermore, dilution effects in random urine samples constitute a major confounder in urinary metabolite detection, with different normalization methods yielding variable correction outcomes for the same metabolite [179]