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When UVA rays penetrate the skin layers, they trigger melanocytes to produce more melanin, leading to darkening

Hakuno et al., 1996

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Toxicity of acetaminophen may cause autism by overloading the defective sulfation pathway catalyzed by phenolsulfotransferase, which is deficient in autism, leading to overproduction of the toxic metabolite N -acetyl- p -benzoquinone imine (NAPQI)